Endocrine Abstracts

An large number of clinical entities are associated with abnormal bone mineral density. On one end of the spectrum, the sclerosing bone dysplasias are characterized by an excess of bone tissue. These conditions are, in most cases, monogenic diseases with involvement of one gene resulting in a clear mode of inheritance. Molecular genetic studies over the last decennia revealed the underlying genetic causes for many of them. The pathogenic mechanism can either be a decreased bon...